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The switchDecoding project investigates the mechanisms behind cell-to-cell variation in the unicellular parasite Trypanosoma brucei, focusing on how this heterogeneity affects surface antigen expression. By employing advanced techniques like single-cell multi-omics and CRISPR-Cas genome manipulation, the project aims t…
Heterogeneity amongst isogenic cells is pervasive throughout biology.
Recently developed single-cell omics approaches are beginning to systematically reveal the repertoire of functionally distinct cell subpopulations within metazoan tissues.
Pathogens frequently encounter changing and often hostile environments.
To adapt to these challenges unicellular pathogen populations also exhibit a large degree of cell-to-cell heterogeneity, which often affects the outcome of infections.
Yet, despite the i…
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
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