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SWItchFate investigates the role of BAF complexes in brain development and disease. By utilizing human stem cell-derived organoids, it aims to uncover how mutations in these complexes affect gene regulation and contribute to neurodevelopmental disorders.
The mammalian SWI/SNF chromatin remodellers, the BAF complexes, are critical regulators of gene expression by modulating the accessibility of regulatory regions, especially of cell identity genes.
Their importance for cellular maintenance and differentiation is emphasised by the fact that they are frequently associated with disease.
Mutations in genes encoding BAF subunits are found in over 20% of cancers and are causative for neurodevelopmental disorders (NDD).
The prevalence for specific NDD w…
INSTITUT FUR MOLEKULARE BIOLOGIE GGMBH
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