CORDIS Project
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This project investigates how variability among cells contributes to the formation of asymmetric structures in intestinal organoids. By analyzing cell behavior and interactions, it aims to uncover the mechanisms behind symmetry-breaking events during development.
Cell-to-cell variability is an inherent property of populations of cells.
As a starting point for symmetry breaking events, it is also an essential building block for self-organised pattern forming systems.
Nonetheless, the sources and roles of cell-to-cell variability in symmetry-breaking events during collective cell behavior await a quantitative and mechanistic understanding.
To obtain these insights, we will use a model system of intestinal organoids, which recapitulates most of the processe…
FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH FONDATION
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