CORDIS Project
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This project investigates how cell adhesion molecules influence synaptic communication in the brain. It aims to understand the role of integrins in regulating synaptic strength and how their dysfunction may relate to neurodevelopmental disorders like autism.
Brain function critically depends on how neurons communicate with each others at specialized contact sites, the synapses.
Cell adhesion molecules (CAMs) are key synaptic proteins that provide the molecular framework for organizing structural and functional aspects of synaptic connections.
However, little is known about the underlying molecular mechanisms.
We do not know how CAMs dynamically regulate synaptic strength in response to trans-synaptic interactions and how alterations in the function…
FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA
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