CORDIS Project
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The SynApoE project investigates how the ApoE4 protein influences tau-related synaptic degeneration in Alzheimer's disease. By examining the interactions between astrocytes and neurons at damaged synapses, the project aims to uncover mechanisms that contribute to cognitive decline, ultimately aiding in the development…
Alzheimers disease (AD) is one of the biggest scientific and socio-economic challenges of the 21st century.
Currently, there is no cure.
Aggregates of amyloid- and tau protein, along with neuroinflammation/gliosis, are hallmarks of AD that lead to synaptic and neuronal loss as the basis for cognitive decline.
The latter correlates closely with the brain distribution of tau aggregates, providing a strong incentive to investigate a link between tau accumulation and synaptic degeneration.Brain apol…
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
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