CORDIS Project
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SynapTau investigates how microglia contribute to tau-related synaptic loss in Alzheimer's disease. By understanding the interactions between tau, synaptic proteins, and glial cells, the project aims to identify new therapeutic strategies to protect synaptic integrity and slow cognitive decline.
The overall aim of SynapTau is to evaluate the contribution of microglia on tau-mediated synaptic loss in Alzheimers disease (AD), based on synaptosomal changes, which may help to develop therapeutic strategies against AD.
Determining the impact of tau accumulation on synaptic loss is critical since it correlates with cognitive decline in AD.
Beyond tau and amyloid- pathologies, gliosis is also an AD hallmark and is thought to play a pivotal role on synaptic loss.
Despite the link between tau, s…
UNIVERSITE D'AIX MARSEILLE
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