CORDIS Project
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This project investigates the genetic factors affecting synaptic function in neurodegenerative diseases using fruit flies as a model. It aims to identify genes involved in vesicle recycling and their interactions with proteins related to Parkinson’s disease, potentially revealing new therapeutic targets.
The nervous system consists of a complex network of neurons interconnected by chemical synapses.
Recycling of neurotransmitter filled vesicles at theses synapses enables neurons to maintain communication during periods of intense activity.
There is accumulating evidence that synaptic dysfunction is, at least in part, responsible for common neurodegenerative diseases such as Alzheimer’s, Huntington’s and Parkinson’s disease. I therefore set out to find genes involved in the synaptic pathogenesis…
Leiden University Medical Center
ACADEMISCH ZIEKENHUIS LEIDEN
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