CORDIS Project
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This research focuses on the role of mitochondria at synapses in managing energy and stress during neurotransmitter release. It aims to uncover how mitochondrial dysfunction contributes to neurodegenerative diseases and to identify key regulatory mechanisms.
Mitochondria at the synapse have a pivotal role in neurotransmitter release, but almost nothing is known about synaptic mitochondria composition or specific functions.
Synaptic mitochondria compared to mitochondria in other cells, need to cope with increased calcium load, more oxidative stress, and high demands of energy generation during synaptic activity.
My hypothesis is that synaptic mitochondria have acquired specific mechanisms to manage local stress and that disruption of these mechanisms…
INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES
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