CORDIS Project
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This project investigates the role of cholesterol in the movement of neurotransmitter receptors within neurons, which is crucial for synaptic plasticity related to learning and memory. By manipulating cholesterol levels in neurons, the research aims to uncover its impact on cognitive functions and disorders.
Synaptic connections in the brain are continuously remodeled in response to neuronal activity.
This process, known as synaptic plasticity, is widely thought to underlie learning and memory, and to be altered in several cognitive disorders.
An important aspect of synaptic plasticity is the regulated movement of neurotransmitter receptors in and out of the synaptic membrane.Cholesterol is an essential membrane component, and it plays a major role in membrane compartmentalization and trafficking. A…
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