CORDIS Project
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The SYNDAM project investigates how the brain identifies and removes damaged proteins at synapses, which are crucial for information transfer and storage. It aims to understand the mechanisms behind protein quality control and clearance during sleep, focusing on oxidative damage and the role of ubiquitin in this proces…
SYNDAM investigates how the brain detects and clears damaged proteins at the primary loci for information transfer and storage— synapses.The synapse expresses many proteins that are mutated or dysregulated in major brain disorders.
The information transfer rate at synapses is high and, as a result, synapses are continuously exposed to oxidative challenges that arise from local mitochondrial respiration and oxidase activity.
This puts synaptic proteins at risk.
This risk is exacerbated by the lon…
AARHUS UNIVERSITET
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