CORDIS Project
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This project investigates how various biological factors influence the phase separation of α-synuclein, a protein linked to Parkinson's disease. Using advanced microfluidics techniques, it aims to clarify the mechanisms behind protein aggregation and its implications for disease progression.
Proteins are among the most essential molecules of life.
In recent times, it has been discovered that proteins can undergo liquid-liquid phase separation (LLPS) to form highly efficient droplet reservoirs for its functionality.
However, these concentrated protein droplets can also lead to pathological protein aggregation and toxic amyloid fibril formation.
One such example is α-synuclein (α-Syn), which can undergo LLPS-mediated amyloid aggregation associated with Parkinson’s disease (PD) pathoge…
TECHNICAL UNIVERSITY OF DENMARK DTU
DANMARKS TEKNISKE UNIVERSITET
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