CORDIS Project
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This project focuses on the role of synaptic ectosomes in immune cell communication. By isolating these microvesicles and studying their composition and function, it aims to enhance understanding of T cell interactions and their implications for immune responses.
The immunological synapse is a highly conserved scaffold for communication between immune cells built around cooperation of antigen and adhesion receptors.
It often takes the form of a bull’s eye with a central cluster of antigen receptors surrounded by a ring of adhesion molecules.
We have recently observed that antigen receptor coated extracellular microvesicles bud directly from the center of the immunological synapse- which we define as synaptic ectosomes.
Synaptic ectosomes are transferred…
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
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