CORDIS Project
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This project investigates the role of the Endoplasmic Reticulum in neurons, focusing on its protein composition and contribution to neurotransmission. By using advanced imaging and proteomics, the research aims to clarify how the Endoplasmic Reticulum affects neuronal functions and its implications for neurodegenerativ…
Brain function relies on neurotransmission at synapses, where local increases in calcium trigger the fusion of synaptic vesicles and release of their neurotransmitters.
Decades of research yielded detailed knowledge on synaptic vesicles and the individual proteins that mediate neurotransmission.
Conversely, we know surprisingly little about the synaptic contribution of the largest organelle in neurons: the Endoplasmic Reticulum (ER).
Aberrant alterations in ER shape are, however, associated with…
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