CORDIS Project
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This project focuses on improving the assembly of complete genomes using synthetic DNA fragments. By utilizing nanofluidic channels, the project aims to enhance the efficiency of DNA hybridization, ultimately leading to a commercially viable platform for genome assembly.
Synthetic genomics is a rapidly growing branch of synthetic biology where the goal is to assemble a complete genome from small synthetic DNA fragments.
The main obstacle is the later stages of assembly where fragments on the kilobasepair length scale are to be assembled, where the efficiency rapidly falls off with increasing fragment size. A large contribution to this bottleneck is purely physical, where the probability of DNA ends meeting decreases with increasing DNA size.
My solution to this…
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