CORDIS Project
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This project investigates the role of melanin-concentrating hormone in Alzheimer's disease, focusing on its impact on neuronal function and inflammation. It aims to understand how disruptions in this system contribute to cognitive decline during the disease's early stages.
Alzheimer’s disease (AD) patients stay in a prodromal phase over many years before robust cognitive decline.
During this phase, complex molecular events lead to cellular alterations, resulting in aberrant synaptic activity and chronic inflammation which leads to neuronal death and cognitive impairment.
My unpublished work, shows that melanin-concentrating hormone (MCH) regulates synaptic function and revealed that the MCH system is impaired in a mouse model of early AD and AD patients. I showed…
UNIVERSIDADE DO MINHO
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