CORDIS Project
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This project focuses on the manipulation of non-ribosomal peptide synthetases to produce novel natural products with potential therapeutic applications. By leveraging advanced molecular techniques, it aims to create new peptides that are not found in nature, enhancing drug development possibilities.
Natural products (NPs) generated by microbial non-ribosomal peptide synthetases (NRPS) represent several very important and valuable clinical antibiotics, immune-suppressive and anti-cancer drugs. NPs have gone on to inspire several synthetic peptides that are used clinically, but contain amino acids (AAs) or other building blocks that are not found in nature.
However, with >500 identified AAs and additional peptide modifications like glycosylation or cyclization, the chemical diversity in NRPS-…
JOHANN WOLFGANG GOETHE-UNIVERSITAET FRANKFURT AM MAIN
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