CORDIS Project
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This project explores how specific DNA sequences regulate gene expression in different cell types, using synthetic biology to create and test variants of gene regulatory domains in mouse embryonic stem cells. The goal is to uncover the complex interactions within these domains that influence gene activity and cell iden…
How the genome controls precise, cell-type specific gene expression is crucial for cell identity and differentiation.
Short cis-regulatory elements, such as enhancers, are distributed in extended regulatory domains surrounding their target gene, which in mammals typically span hundreds of kilobases.
Although all evidence indicates that gene regulation is controlled by the combined action of large domains, our current understanding mostly focuses on enhancers.
If and how intervening DNA sequences…
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