CORDIS Project
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This project investigates the role of TDP-43 protein in Alzheimer's Disease, focusing on its impact on synaptic function and cognitive decline. Using various models, it aims to uncover how TDP-43 loss affects RNA targets linked to synaptic health, providing insights into neurodegeneration mechanisms.
Alzheimer’s Disease (AD) is an adult-onset disorder characterized by progressive neuronal loss and synaptic dysfunction, leading to severe cognitive decline.
Nuclear loss and pathological inclusions of TDP-43 protein have been identified in 20-50% of AD patients, which associate with higher odds of cognitive decline, and faster brain atrophy rates. TDP-43 regulates RNA metabolism, and many of its RNA targets converge at synaptic function.
Studies from me and others identified TDP-43 dependent mi…
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