CORDIS Project
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This project investigates the sensitivity of BRCA1 and BRCA2 deficient cells to the loss of other DNA repair mechanisms. By using high-throughput RNA interference screenings, it aims to identify potential therapeutic targets for cancers associated with these mutations, ultimately contributing to the development of new…
Mutations in BRCA1 and BRCA2 genes confer high lifetime risks of developing breast and other cancers.
Moreover, several studies suggest that tumours arising in mutation carriers have generally lost the wild-type allele and do not express functional BRCA1 or BRCA2 proteins.
Both BRCA proteins are important for repair of double strand DNA breaks by homologous recombination.
The subject of this project would allow us to clarify if cells harbouring defects in DNA damage repair (such as BRCA1 deficie…
INSTITUTE OF CANCER RESEARCH: THE ROYAL CANCER HOSPITAL LBG
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