CORDIS Project
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This project investigates the roles of vesicular glutamate transporters in synaptic function, focusing on their influence on glutamate release and synaptic plasticity. It aims to understand how these transporters affect neurotransmitter dynamics and their implications for mental health conditions.
This proposal describes experiments aimed at defining the multiple roles of vesicular glutamate transporters (VGLUTs) in central synapses.
Classically, VGLUTs transport glutamate from the cytoplasm into synaptic vesicles.
Deletion of these genes disrupts synaptic glutamate release and their expression suffices to determine neurons as glutamatergic.
We recently discovered that VGLUTs control additional key parameters such as quantal size and vesicular release probability, suggesting that they are…
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