CORDIS Project
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The SYNVIA project investigates the mechanisms behind cancer treatment resistance in BRCA1- and BRCA2-deficient breast cancer using advanced mouse models. By employing next-generation sequencing and CRISPR technology, the project aims to uncover new resistance mechanisms and improve therapeutic strategies for patients.
Although various effective anti-cancer drug treatments have become available over the last decades, drug resistance remains the major cause of death of cancer patients.
Striking examples are patients with tumors that are defective in DNA repair by homologous recombination (HR).
Despite initial responses to cancer therapy, resistance of primary or disseminated tumors eventually emerges, which minimizes therapeutic options and greatly reduces survival.
The molecular mechanisms underlying this ther…
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