CORDIS Project
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This project aims to synthesize two marine natural products, waixenicin A and xenibellol A, using a novel organocatalytic method. These compounds show promise as potential anticancer agents, addressing a significant gap in therapeutic applications due to the lack of synthetic access.
The realization of the first total syntheses of the two marine natural products waixenicin A and xenibellol A is the aim of this proposal.
For this purpose, a N-heterocyclic carben (NHC)-catalyzed bicyclization shall be employed as key transformation.
Both target structures are members of the Xenia diterpenoids family and exhibit cytotoxicity against human cancer cell lines.
Despite these highly desirable, promising biological properties and unique structural features, therapeutic applications h…
UNIVERSITAET INNSBRUCK
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