CORDIS Project
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This project investigates the role of GABA, an inhibitory neurotransmitter, in the formation of synapses during brain development. It aims to clarify how changes in chloride levels influence synapse formation and the timing of these processes within neurons.
In adults, GABA acts as the primary inhibitory neurotransmitter, but during early development, GABAergic synaptic transmission has depolarising effects and can influence various developmental processes.
The role of depolarising GABA in synapse formation remains unclear.
Specifically, whether changes in intracellular chloride concentration influence synapse formation directly or whether it occurs concomitantly with it is not known.
Moreover, the specifics of how and where this process unfolds acr…
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