CORDIS Project
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This project investigates the interactions between fungal colonization, bacterial flora, and host genetics in relation to Candida albicans infections. By mapping these interactions, the research aims to identify new therapeutic targets for conditions like recurrent vulvovaginal candidiasis and disseminated candidiasis.
Fungi such as Candida albicans are ubiquitous colonizers of human skin and mucosa.
Fungal pathogens invade the host when host defence is diminished, and the combination of fungal and bacterial colonization modulates mucosal and systemic immune responses.
Little is known of the complex interaction between fungal and bacterial colonization, as well as between these two and the host genome and immunity.
The Hypothesis of this proposal is that immunity to C. albicans is determined by the interaction…
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