CORDIS Project
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This project focuses on understanding the biology and regulation of dendritic cell subsets in both mice and humans, particularly their roles in antiviral and antitumoral immunity. By employing a systems biology approach and comparative genomics, the aim is to uncover key functions that can inform the development of mor…
The development of better vaccines against cancer or intracellular pathogens is a major challenge of immunological research.
Novel approaches are needed to induce efficient, long-lasting memory CD8 T cell (CTL) responses.
The CD8α subset of mouse dendritic cells (mDC) is specialized in this function, excelling at antigen cross-presentation.
Their targeting in vivo for vaccination yielded encouraging results.
How to translate this strategy for human health was not obvious, because no human DC (hD…
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
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