CORDIS Project
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This project investigates how genetic variations influence phenotypic diversity in yeast. By systematically engineering and profiling genetic variants, it aims to reveal their effects on fitness and cellular processes across different environments and genetic backgrounds.
Despite the ubiquity of genome sequence data, unravelling the contributions of genetic variation to phenotypic diversity remains one of the greatest challenges in genomics.
This is partly due to our very limited knowledge of how multiple variations combine to create phenotypes.
There is a clear need for a systematic, perturbation-based approach to study the phenotypic consequences of genetic variants in different genomic and environmental contexts.
Previous efforts have primarily used loss-of-fu…
EUROPEAN MOLECULAR BIOLOGY LABORATORY
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