CORDIS Project
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This project investigates the role of the EPHA3 receptor in cancer development, particularly its mutations in lung and colorectal cancers. By studying cellular responses to these mutations, it aims to uncover mechanisms of tumor suppression and potential cancer prevention strategies.
Cells contain in-built checkpoint mechanisms to halt division when cells are somehow compromised in their ability to replicate properly, allowing time to repair or adjust the inflicted machinery.
If the damage signal persists, cells eventually undergo irreversible cellular faiths, including cellular senescence or apoptosis.
Of interest to cancer researchers, apoptosis and senescence upon prolonged oncogene activation or loss of tumor suppression is an emerging paradigm, and is even detected in e…
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