CORDIS Project
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This project explores the role of T-cell mediated immunity in responses to Staphylococcus aureus infections. It aims to identify specific antigens that induce T-cell responses and evaluate their behavior under inflammatory conditions to inform vaccine development.
Antibodies against bacterial polysaccharides and proteins play a role in anti-bacterial immunity.
To date, S. aureus vaccine candidates were selected to induce functional antibody responses.
However, a potential role for T-cell mediated immunity is emerging, supported by the fact that impaired Th17 responses in patients with hyper IgE syndrome are linked to abnormal susceptibility to S. aureus infections.
Thus, the capacity to induce specific T cell responses may be an important criterion to sel…
GLAXOSMITHKLINE BIOLOGICALS SA
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