CORDIS Project
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The T-FITNESS project aims to enhance the effectiveness of T cell therapies for solid tumors by preventing T cell exhaustion. Utilizing microRNA-based synthetic circuits and CRISPR/Cas genome editing, it seeks to reprogram T cells to maintain their antitumor functions, ultimately improving cancer treatment outcomes.
Cell and gene therapies offer a massive paradigm shift from current treatment options and hold the potential to cure previously untreatable diseases.
Naturally-occurring and genetically modified T cells with chimeric antigen (CAR) or T cell receptors (TCR) have demonstrated remarkable curative capacities against advanced hematologic malignancies but have shown limited efficacy in treating solid tumors.
Major barriers hindering the full antitumor potential of T cells are the immunosuppressive sig…
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Germany, Bergisch Gladbach
Type: Company (for-profit)
Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
SME: No
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