CORDIS Project
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This project investigates the structure and function of a protein called BteA from Bordetella bronchiseptica, which is involved in cell death mechanisms. The research aims to provide insights into host-pathogen interactions and identify new targets for antibiotic development.
Bordetella pertussis, B. parapertussis and B. bronchiseptica are Gram-negative bacteria that colonize the respiratory tracts of mammals. B. pertussis has adapted exclusively to the human host and is known to be the causative agent of whooping cough (pertussis).
Bordetella bacteria use the type III secretion system (T3SS) to establish persistent colonization of the trachea and to modulate the host immune response.
They encode a highly conserved type III secretion effector protein, BteA, which is…
BEN-GURION UNIVERSITY OF THE NEGEV
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