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The Transcriptional Adaptation and Genetic Compensation project explores how certain gene regulation mechanisms can compensate for harmful mutations. By using splice-switching antisense oligonucleotides, the project aims to induce transcriptional adaptation in human cells, potentially leading to new therapies for Duche…
Organisms display various mechanisms to compensate for the deleterious effects of harmful mutations.
One such mechanism is transcriptional adaptation (TA), a recently identified mode of gene regulation whereby mutant mRNA decay triggers the transcriptional modulation of so-called adapting genes, independently of protein loss (Rossi et al., Nature 2015;
El-Brolosy et al., Nature 2019).
In some cases, TA can lead to functional compensation by upregulating genes that are functionally redundant wi…
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
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