CORDIS Project
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This project develops a novel bioorthogonal labelling method to study disease-related proteins in live cells. By using small, genetically encoded amino acids, it aims to label proteins without disrupting their function, enabling better understanding of cancer biology and the creation of targeted treatments.
The ability to probe dynamic cellular events that involve disease-associated proteins is limited, to a large extent, by the lack of development of a strategy that can use small coupling partners to react in chemoselective fashion with rapid kinetics that does not interfere with biological function(s) and localisation.
In this application, I describe a conceptually new bioorthogonal-labelling approach that combines the introduction of a minimal non-canonical amino acid with chemoselective reactio…
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