CORDIS Project
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This project investigates the role of Natural Killer cells in sepsis, focusing on how limiting amino acid availability can reduce inflammation and improve outcomes. It combines mouse models and metabolic analysis to explore new therapeutic strategies for managing sepsis.
Sepsis is a global health challenge, accounting for around 20% of deaths worldwide.
While sepsis is induced by uncontrolled dissemination of infection, significant contribution to disease pathogenesis is made by overwhelming production of proinflammatory mediators, a so-called “cytokine storm”.
There is a pressing need for new target therapies to dampen this immunopathogenesis while still allowing bacterial clearance.
Although Natural Killer (NK) cells are vital for host innate responses, they a…
THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN
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