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This project focuses on developing new neuroprotective therapies for glaucoma by targeting NAD metabolism. It aims to create both drug and gene therapy approaches to protect neurons and promote axon regeneration, with the goal of transitioning findings to clinical applications.
The goal of this ERC Advanced Grant is to develop clinically translatable neuroprotective strategies for glaucoma by focusing on NAD metabolism. NMNAT2 is a neuron-specific NAD-generating enzyme and is the upstream enzyme that coordinates axon degeneration.
The Williams lab is expert in taking basic biological findings in glaucoma to the clinic, and we will leverage our expertise in this space to develop novel clinically translatable therapeutic interventions for glaucoma based on NMNAT2 biology…
KAROLINSKA INSTITUTET
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