CORDIS Project
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This project focuses on the role of Ubiquitin Carboxy-Terminal Hydrolase L1 in cellular regulation and its implications in diseases like cancer and neurodegeneration. It aims to develop probes and inhibitors to study UCHL1's function and potential therapeutic applications.
Modification of proteins with ubiquitin (Ub), itself a small protein, is a fundamental mechanism involved in regulation of almost all cellular functions.
There are hundreds of enzymes involved in the addition or removal of Ub, and this system has emerged as an important drug target in many diseases.
Ubiquitin Carboxy-Terminal Hydrolase L1 (UCHL1) is a member of the UCH family of deubiquitinases (DUBs), and is the most abundant protein in the brain. UCHL1 dysregulation has been shown to be associ…
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