CORDIS Project
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This project focuses on validating Greatwall Kinase as a target for cancer therapy. By selectively targeting this kinase, which is critical for the survival of cancer cells but not essential for normal cells, the project aims to develop novel treatments that minimize side effects associated with traditional cancer ther…
The progression of cells through mitosis is tightly regulated to ensure the integrity of chromosomal transmission and cell division.
The proper orchestration of mitotic progression is controlled by the balanced activity of mitotic kinases and counteracting phosphatases.
Misregulation of these controls can be detrimental causing loss of entire chromosomes and aneuploidy.
Considering that mitotic kinases are only expressed in actively dividing cells, targeting these kinases for cancer management i…
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