CORDIS Project
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This project focuses on developing new therapies for gastrointestinal stromal tumors (GIST) by utilizing targeted protein degradation to overcome resistance to existing treatments. The aim is to design and optimize degraders that can effectively destroy the KIT protein, which drives GIST progression, using innovative d…
Gastrointestinal stromal tumour (GIST) is the most common subtype of sarcoma in humans and its initiation and progression is predominantly driven by constitutively activating mutations in the receptor tyrosine kinase (RTK) KIT.
This dependency on KIT led to the approval of kinase inhibitors for the treatment of GIST.
Inhibition of KIT activity is effective at treating GIST in the short-term however, the majority of patients eventually develop resistance.
This resistance is predominantly due to t…
FUNDACIO INSTITUT DE RECERCA BIOMEDICA (IRB BARCELONA)
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