CORDIS Project
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This project aims to develop a targeted drug delivery system for inflammatory bowel disease by using phospholipase A2 to activate prodrugs specifically in diseased tissues. It focuses on creating and testing phospholipid-drug conjugates to enhance therapeutic efficacy while minimizing side effects.
A molecular approach will be applied to mechanistically target drugs - by exploiting phospholipase A2 (PLA2) - to diseased tissues in inflammatory bowel disease (IBD). PLA2 hydrolyses the sn-2 fatty acyl bond of phospholipids (PL), liberating a fatty-acid and a lysophospholipid.
We have shown that by substituting the sn-2 fatty-acid of the PL with a drug, PLA2 may be exploited as a prodrug activating enzyme, liberating the free drug from the PL-complex.
Further, PLA2 affinity to the prodrug and…
BEN-GURION UNIVERSITY OF THE NEGEV
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