CORDIS Project
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This project explores a novel cancer treatment strategy using a targeted vector to deliver RNA to tumors overexpressing the epidermal growth factor receptor. The approach aims to harness the immune system's bystander effects for effective tumor eradication.
We have recently shown that EGFR over-expressing tumors can be eradicated by an EGFR homing chemical vector, carrying dsRNA.
The vector is PolyInosine/Cytosine (PolyIC) bound to Polyethleneimine-Polyethyleneglycol-EGF (PEI-PEG-EGF, PPE).
We have shown that even tumors in which up to 50% of cells do not express EGFR are eradicated, due to the strong tumor-localized bystander effects, which involve the innate immune system.
Using this EGFR homing vector we have been able to eradicate EGFR overexpr…
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