CORDIS Project
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This project explores the role of activation-induced deaminase in antibody formation and its implications for genetic regulation. By analyzing the interactions of this enzyme with transcription complexes, it aims to uncover mechanisms that influence immune diversity and potential disease pathways.
In B cells, antibody repertoire is created via two DNA instability complexes, one of which uses DNA cytosine deamination and is needed for immunoglobulin (Ig) diversification.
Targeting of DNA deamination is poorly understood and mis-targeting can lead to genetic pathologies.
Activation induced deaminase (AID) catalyses the hydrolytic deamination of cytosine residues, with the resulting uracil inducing DNA instability leading to Ig diversification.
Recently AID has been implicated in inducing de…
IFOM-ISTITUTO FONDAZIONE DI ONCOLOGIA MOLECOLARE ETS
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