CORDIS Project
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This project investigates the NOTCH signaling pathway, which is crucial for embryonic development and tissue maintenance. It focuses on understanding how mutations affect receptor cleavage and signaling, aiming to develop therapeutic strategies for diseases like cancer by targeting metalloprotease activity.
NOTCH signaling is a highly conserved short-range signaling pathway involved in virtually every aspect of embryonic development and controls homeostatic self-renewal in many adult tissues.
Germ line mutations in the NOTCH pathway cause several hereditary diseases, and somatic mutations are found in cancer. NOTCH pathway activity is governed by ligand induced proteolytic cleavage of the receptor in the extracellular domain by a metalloprotease.
This cleavage is required for the consecutive transm…
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Netherlands, Utrecht
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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