CORDIS Project
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TargetNCREs focuses on exploring non-coding regulatory elements in the human genome to identify potential therapeutic targets. The project aims to develop high-throughput screening systems to validate these targets for future commercial applications in genetic therapies.
The 98% of the human genome, sometimes referred to as the dark side of the human genome, contains many non-coding regulatory elements (NCREs), which control the combinational expression of the limited number of genes (only 2% of the genome) to form diverse cell types and tissues of a complex human body, all from the identical copy of the genome.
Most genetic variants and mutations also lie in NCREs.
However, the number of NCREs as potential therapeutic targets remains very limited.
In TargetNCRE…
Leiden University Medical Center
ACADEMISCH ZIEKENHUIS LEIDEN
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