CORDIS Project
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This project explores the mechanisms behind genome instability, a factor in cancer development, focusing on R-loops and their role in transcription-associated recombination. It aims to identify genetic factors influencing R-loop dynamics.
Understanding the causes of genome instability, a condition linked to cancer and cancer-prone genetic diseases, is a major question in Molecular Biology and Biomedicine.
Probably the most important natural cause of genome instability is transcription, which is known to induce both mutation and recombination from bacteria to human cells.
Different studies suggest that transcription-associated recombination (TAR) is in large part due to collisions between transcription and replication, but increas…
UNIVERSIDAD DE SEVILLA
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