CORDIS Project
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This project explores the potential of targeting the Myc transcription factor to inhibit tumor growth. By investigating its role in gene regulation and developing new drugs, the research aims to advance cancer therapy strategies.
The transcription factor Myc plays a central role in tumourigenesis but was deemed undruggable due to it being an essential protein.
However, recent proof-of-principle studies in mice using a dominant negative allele of Myc demonstrated the dependency of established tumours on Myc function and showed that mice tolerated Myc inhibition to a degree that allowed tumour regression.
In line with these observations my group found Myc to regulate distinct sets of genes at low, physiological and high, o…
JULIUS-MAXIMILIANS-UNIVERSITAT WURZBURG
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