CORDIS Project
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This project focuses on understanding oxidative DNA damage and repair mechanisms linked to various diseases. It aims to develop small molecule inhibitors targeting specific enzymes to enhance therapeutic approaches for conditions like cancer and inflammation.
Oxidative damage and defects in DNA repair are frequently underlying many diseases, e.g., cancer, autoimmune diseases, ischemia/reperfusion injury, neurodegenerative disorders, viral diseases and ageing.
Although some molecular understanding into oxidative DNA lesions and repair proteins exist, a thorough understanding on the link to diseases is largely missing, and therapies exploiting oxidative DNA damage and repair have not emerged.
Here, we will study mechanisms of nucleotide metabolism and…
KAROLINSKA INSTITUTET
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