CORDIS Project
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This project investigates the genetic factors influencing susceptibility to tuberculosis by analyzing the genomes of 6,000 patients and 6,000 healthy controls. It aims to identify genetic variants that affect gene expression in macrophages, which are crucial for the immune response against tuberculosis.
Tuberculosis (TB) is a major global problem that urgently requires new preventive and therapeutic approaches.
Only minority of people infected with M. tuberculosis develops active TB.
Genetic studies provide an unbiased way to scan the whole human genome to find sequence polymorphisms that predispose to TB.
Therefore, we have established the world s largest sample collection for TB genetic studies.
Now we genotype 6,000 HIV-negative patients with pulmonary TB and 6,000 healthy controls at ~1 mil…
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