CORDIS Project
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This project explores how fetal male germ cells manage the activity of transposable elements during development. By analyzing epigenetic changes, it aims to uncover mechanisms that allow these cells to protect genomic integrity, with implications for reproductive biology and related health issues.
Mammalian genomes are filled with transposable elements (TEs), whose activity is usually silenced by DNA methylation.
However, during the fetal phase of germline development, DNA methylation is naturally lost as part of the epigenetic reprogramming of the future gametes.
This leads to the transcriptional activation of transposition-competent TEs, which normally represents a threat to genomic integrity and species fitness.
How fetal male germ cells (a.k.a. prospermatogonia) mechanistically cope w…
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