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TeaM develops a synthetic biology approach to enhance immune cell therapies for solid tumors. By engineering T cells and macrophages with synthetic communication systems, the project aims to overcome the challenges posed by the immunosuppressive tumor microenvironment, enabling targeted therapeutic responses.
In TeaM I propose a synthetic biology-based multi-cellular strategy to fight solid tumors, addressing the immunosuppressive tumour microenvironment (TME). WHY:
Synthetic biology is transforming cell-based immunotherapies with control circuits in immune cells like T cells and macrophages.
However, in solid tumours the TME renders these cells dysfunctional, limiting their efficacy.
Innovative solutions are needed to address this unmet need and unlock the full potential of immunotherapies.WHAT:
Tea…
FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA
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