CORDIS Project
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This project explores the differentiation of thymic epithelial cells, which are crucial for T cell development and immune tolerance. By investigating the genetic and epigenetic factors involved, it aims to improve our understanding of immune responses and potential therapies for immune-related disorders.
The development of vaccines for the treatment of infectious diseases, cancer and autoimmunity depends on our knowledge of T-cell differentiation.
This proposal is focused on studying the thymus, the organ responsible for the generation of T cells that are responsive against pathogen-derived antigens, and yet tolerant to self.
Within the thymus, thymic epithelial cells (TECs) provide key inductive microenvironments for the development and selection of T cells that arise from hematopoietic progeni…
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