CORDIS Project
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This project investigates epigenetics, focusing on heritable changes in gene expression without altering DNA. It aims to develop specific inhibitors for histone-modifying proteins, which play a crucial role in various diseases, to enhance therapeutic options.
Epigenetics is the study of heritable changes in phenotype that does not involve changes in the underlying DNA sequence.
Epigenetic modifications are partly inherited, but unlike the genome itself, are cell specific, plastic, and its mechanisms are affected by different factors and processes such as aging, environmental factors or the use of drugs.
The epigenetic changes are the result of epigenetic tags (chemical tags) that can determine gene expression.
There are two main types of epigenetic m…
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
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